对结核病后肺病的临床模式有了新的理解
H Thomson1, N Baines2, T Huisamen2
1King's College Hospital, London, UK;, Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Cape Town.
概括
结核病后肺部疾病 (PTLD) 影响年轻人,死亡率高. 独特的临床模式与特定的症状和结果有关,为管理这种疾病提供了新的见解.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 结核后肺病 (PTLD) 呈现出各种生理,放射和临床异常.
- 这些独特的PTLD模式的临床意义在很大程度上仍然未知.
- 对于经历高发病率和死亡率的PTLD患者的长期结果的预测因素尚不清楚.
研究的目的:
- 调查不同PTLD模式的临床意义.
- 确定临床模式和患者结果之间的关联.
- 了解PTLD的长期结果的预测因素.
主要方法:
- 在南非进行了一项观察性研究.
- 185名PTLD患者从第三级医院招募.
- 收集的数据包括人口统计,风险因素,症状,肺功能和结果.
主要成果:
- 一半的患者以前只有一次结核病 (TB) 发作.
- 与结核病相关的阻塞性肺病 (OLD) 与呼吸障碍,胸痛和吸烟有显著的相关性.
- 血液溶解与化和真菌疾病有显著的关联.
结论:
- 晚期TLD甚至在单次结核病发作后也会影响年轻人,并且与高死亡率有关.
- 截然不同的PTLD临床模式具有有意义的差异.
- 与结核病相关的OLD与呼吸不良,胸痛和吸烟有关,而血与腔腔和真菌疾病有关.
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