血清海斯H4水平可以成为性结肠炎的生物标志物吗?
İrfan Küçük1, Fatih Özçelik2, Yusuf Yazgan3
1Department of Gastroenterology, University of Health Sciences Sultan 2. Abdulhamid Han Training and Research Hospital, İstanbul, Turkey.
概括
与健康对照组相比,性结肠炎患者的血清海斯H4水平显著降低. 下素H4可以作为性结肠炎的辅助诊断标记物,诊断准确度为0.782.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 生物化学 生物化学
背景情况:
- 中性细胞外细胞陷 (NET) 分子,包括基质子,在炎症性疾病中显示出诊断潜力.
- 基因组是NET的组成部分,在先天免疫和炎症中发挥作用.
研究的目的:
- 研究血清海斯顿H4作为性结肠炎 (UC) 的诊断和预后生物标志物的潜力.
- 评估血清海斯顿H4水平与UC患者疾病严重程度和临床参数的相关性.
主要方法:
- 一项病例控制研究,涉及58名UC患者和45名健康对照.
- 使用酶相关免疫吸收试验 (ELISA) 量化血清中海斯H4水平.
- 使用梅奥得分和组织学活动指数评估了临床和组织学疾病活性.
主要成果:
- 血清海斯顿H4在UC患者中明显低于对照组 (268比598ng/L,P<.001).
- 在UC患者的血清组素H4和疾病程度,临床分数或炎症标志物之间没有发现显著的相关性.
- 接收器操作特征 (ROC) 分析表明,在区分UC时,血清海斯H4的诊断准确率为0.782,敏感度为72.4%,特异性为88.9%,截止值为≤364 ng/L.
结论:
- 血清海斯H4的降低可能作为诊断的辅助标记,并可能导致性结肠炎的进展.
- 需要进一步的研究,以充分阐明血清素H4与UC的临床和实验室特征之间的关系.
相关概念视频
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
117
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
117
01:30Serum Laboratory Studies, Stool Test, Breath Test
346
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
346