在解释血清中25-基维生素D水平时需要考虑的因素
Joris R Delanghe1, Marijn M Speeckaert2,3, Thomas Maenhout1
1Labo Maenhout, Waregem, Belgium.
准确的维生素D评估需要考虑季节性变化和个人因素,如身体成分. 个性化维生素D疗法通过考虑这些关键元素以达到最佳25-基维生素D水平,确保有效的治疗.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 临床化学 临床化学
背景情况:
- 通过血清25-基维生素D [25(OH) D]评估维生素D的状况因多种因素而复杂化.
- 个人维生素D水平因季节性,遗传学 (DBP多态) 和身体成分 (脂肪性) 而波动.
研究的目的:
- 为了突出评估维生素D状态的复杂性.
- 强调需要个性化维生素D补充和治疗的需要.
主要方法:
- 使用cosinor函数对25...OH) D水平进行地理季节性影响的调整.
- 考虑用于量身定制的维生素D补充剂的DBP基因型/表型,特别是在透析患者中.
- 实施基于体质的调整,以准确评估极端BMI的个体的维生素D,并考虑到肥胖的影响.
主要成果:
- 季节性显著影响了个体内25(OH) D的变化.
- 透析患者的DBP 2-2表型表明维生素D的需求更高.
- 肥胖与维生素D度有负相关性,需要根据BMI进行调整.
结论:
- 个性化维生素D替代疗法是必不可少的.
- 治疗必须考虑身体大小和季节性变化,以有效地实现25...OH) D目标.
更多相关视频
06:43A Quantitative Assay to Study Protein:DNA Interactions, Discover Transcriptional Regulators of Gene Expression, and Identify Novel Anti-tumor Agents
Published on: August 31, 2013
11:30A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
相关概念视频
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Skeleton and Calcium Homeostasis
Cholesterol: Significance and Regulation
Considering cholesterol and...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
