在健康和并发妊娠期间的活性血氨酸度:系统性审查和元分析
Wisal El Fathi1, Maaike van Ochten2, Munieb Rehman3
1Department of Gynecology and Obstetrics, Radboud University Medical Center, Nijmegen, The Netherlands.
Reproductive biology and endocrinology : RB&E
|March 8, 2024
概括
活跃血仁度 (APRC) 在健康怀孕中显著上升,但在高血压怀孕中并非如此. 这一发现突出了怀孕并发症期间的氨酸- ангиотензин- 阿尔多素系统 (RAAS) 调节的关键差异.
科学领域:
- 心血管生理学心血管生理学
- 生殖内分泌学 生殖内分泌学
背景情况:
- 怀孕涉及到显著的循环调整和氨酸-血管酶-阿尔多斯特系统 (RAAS) 修改.
- 改变RAAS调节可能在怀孕期间与血管并发症发生之前或同时发生.
研究的目的:
- 在健康的怀孕中,系统地审查和元分析活性血二烯度 (APRC) 的轨迹.
- 为了比较健康怀孕中的APRC水平与复杂的高血压怀孕.
主要方法:
- 对正常血压和高血压妊娠中APRC研究的系统审查和元分析.
- 包括与孕妇和非孕妇参考组进行的研究.
- 随机效应模型和元回归来分析妊娠年龄的APRC趋势.
主要成果:
- 从怀孕早期开始,APRC显著增加,并且在健康怀孕中在整个妊娠期间保持升高 (ROM 2.77;95% CI 2.26-3.39).
- 与非孕妇水平相比,高血压并发症怀孕的APRC没有显著差异 (ROM 1.32;95% CI 0.97-1.80).
结论:
- 健康怀孕的特点是APRC的大幅增加,从第一季度开始,持续到期.
- 在高血压并发症怀孕中,预期的APRC上升不存在,这表明RAAS的调节失调.
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