在一个多地点纵向研究中,产前多环芳暴露和8-9岁的喘在一个多地点纵向研究中
Allison R Sherris1, Christine T Loftus2, Adam A Szpiro3
1Department of Environmental and Occupational Health Sciences, University of Washington4225, Roosevelt Way NE, Suite 300, Seattle, WA, 98105, US. asherris@uw.edu.
产前暴露于多环芳 (PAHs) 显示与儿童喘的联系有限. 在女孩身上发现了一些不良影响,但在这项大型研究中,整体相关性并不强烈.
科学领域:
- 环境健康 环境健康
- 儿童喘研究 儿童喘研究
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于多环芳 (PAHs) 与儿童早期喘息有关.
- 产前PAH暴露对中儿童期喘的长期影响尚不清楚.
研究的目的:
- 调查产前PAH暴露与中儿童期喘/喘息轨迹之间的关联.
- 检查孩子的性别对潜在效果的改变.
主要方法:
- 分析了来自ECHO PATHWAYS联盟的1081个父子双.
- 在怀孕期间测量了孕妇尿液单氧化PAH代谢物 (OH-PAHs).
- 喘和喘息在8-9岁时被评估;使用回归模型,调整混因素.
主要成果:
- 10%的儿童在8-9岁时患有喘.
- 在产前OH-PAH水平和喘或喘息之间发现了有限的不良关联.
- 对于女孩的1/9-hydroxyphenanthrene,观察到一些不良关联;对于男孩的1-hydroxynaphthalene,观察到相反的关联.
结论:
- 在这个队列中,没有强有力的证据将产前PAH暴露与8-9岁的喘联系起来.
- 观察到一些特定于性别的关联,需要进一步调查.
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