CircPVT1在癌症进展中的新兴作用
Shijie Wu1, Yan Hu1, Xiaoyong Lei1,2
1School of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
Current pharmaceutical biotechnology
|March 8, 2024
概括
像CircPVT1这样的循环RNA (CircRNA) 是人类组织和生物流体中发现的稳定分子. CircPVT1在瘤中表达高,影响癌症的进展,并可能作为一种新的瘤标志物.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 循环RNAs (CircRNAs) 是一种内源性RNA分子,其特点是稳定,共价性闭环结构.
- 循环RNA在人体组织和生物流体中丰富,在生理和病理过程中起着至关重要的作用.
- CircPVT1,来自于癌症风险区域8q24中的PVT1基因,是内源性circRNA的一个例子.
研究的目的:
- 总结CircPVT1.1的生物合成和生物功能.
- 分析CircPVT1表达与各种类型的瘤之间的关系.
- 评估CircPVT1在癌症诊断,治疗和预后方面的重要性.
主要方法:
- 文献综述和对CircPVT1.1现有研究的综合.
- 分析报告不同瘤类型中CircPVT1表达水平的研究.
- 对CircPVT1对癌细胞行为的功能影响的实验数据的检查.
主要成果:
- 在许多人体瘤中,CircPVT1的表达很高.
- CircPVT1影响关键的癌症特征,包括细胞增殖,细胞亡,入侵和迁移.
- CircPVT1的表达模式和功能作用表明它参与瘤发生.
结论:
- CircPVT1在各种癌症的发展和进展中发挥着重要作用.
- CircPVT1有可能成为癌症患者的诊断生物标志物和治疗点.
- 对CircPVT1的进一步研究可能会导致癌症管理的创新策略.
相关概念视频
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Cancer Cell Migration through Invadopodia
2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Cancer-Critical Genes I: Proto-oncogenes
8.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K


