在患有寡进性割抵抗性前列腺癌的患者中进行进展定向治疗
Jun Nyung Lee1, Mi Young Kim2, Jae Hoon Kang1
1Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.
Investigative and clinical urology
|March 8, 2024
概括
进展导向疗法 (PDT) 有效地管理割抵抗性前列腺癌 (CRPC) 中的寡进性病变. 这种方法可以延缓疾病的进展,并改善治疗结果,具有良好的耐受性.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 前列腺癌研究 研究前列腺癌研究
背景情况:
- 寡进性病变发生在割抵抗性前列腺癌 (CRPC) 患者的一个子集中.
- 这些病变进展,尽管系统治疗控制了其他部位.
研究的目的:
- 评估进展导向治疗 (PDT) 对CRPC中的寡进性病变的影响.
- 评估PDT是否能提高治疗效率并延缓疾病的进展.
主要方法:
- 对40名患有寡进性疾病的CRPC患者的回顾性研究.
- 使用放射治疗的PDT被用于所有进展性部位.
- 与PDT组 (n=15) 和非PDT组 (n=25) 的比较,与PDT的子组进行不变或新的全身治疗.
主要成果:
- 与非PDT组相比,PDT组的前列腺特异性抗原 (PSA) 值显著降低 (p=0.007).
- 在PDT组中观察到更高的PSA下降率 (50%和完整).
- PDT,特别是新系统疗法 (PDT-B),显著延长了无PSA进展的生存期和进展的时间.
结论:
- 在CRPC中,PDT有效地控制了寡进性病变.
- PDT可以延缓疾病的进展,提高治疗效率.
- PDT显示了可接受的耐受性与最小的不良事件.
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