生殖激素,甲状腺功能和维生素水平与早泄的关联:一项前性病例对照研究
Yasar Pazır1, Haydar Guler2, Taha Burak Bulut3
1Department of Urology, Haseki Training and Research Hospital, Istanbul, Türkiye.
Investigative and clinical urology
|March 8, 2024
概括
较低的维生素B12水平与早泄 (PE) 有关. 这一发现表明,维生素B12测试可能有利于评估PE男性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 早泄 (PE) 是一个常见的男性性功能障碍.
- 发育不良的病因因素是多因素的,包括心理,关系和生物方面的因素.
- 荷尔蒙和维生素缺乏与PE的病理生理学有关.
研究的目的:
- 调查血清中激素水平 (,益生菌,淋腺激素,甲状腺激素) 和维生素 (B12,叶酸,D) 与早泄 (PE) 之间的关联.
主要方法:
- 一项前性病例控制研究,涉及126名被诊断患有PE (终身和获得) 的患者和92名健康对照.
- 测量了血清中总的水平,自由和生物可用的,卵泡刺激激素,白质化激素,益生素,甲状腺刺激激素,自由三甲状腺素,甲状腺素 (fT4),维生素B12,叶酸和维生素D.
- 对PE的诊断符合国际性医学协会的标准.
主要成果:
- 与对照组相比,PE患者的血清总 (TT),fT4和维生素D水平显著提高.
- 在PE组中,血清维生素B12水平显著降低.
- 多变量逻辑回归确定了维生素B12作为PE的独立风险因素 (OR 0.997,95% CI 0.994-0.999,p=0.036).
结论:
- 较低的血清维生素B12水平与早泄的存在有关.
- 维生素B12缺乏可能在PE的病理生理学中发挥作用.
- 测量维生素B12水平可能是对PE男性临床评估的一个有价值的组成部分.
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