长期的眼睛结果在先天性托克索普拉斯莫斯治疗围产期治疗
Antoine Journé1, Justus Garweg2, Eléa Ksiazek1
1CHU Dijon-Bourgogne, Inserm, Université de Bourgogne, CIC1432 Module Epidémiologie Clinique, Dijon, France.
Pediatrics
|March 8, 2024
概括
先天性毒素瘤 (CT) 可以导致终身的眼睛问题,如视网膜炎. 定期的后续检查至关重要,即使是产前查,因为眼睛问题在成年后也会出现.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 先天性毒素瘤 (CT) 可以导致终身的眼部并发症,特别是视网膜炎.
- 自1992年以来,法国的强制性产前查旨在减少CT发病率.
- 了解长期的眼科预后对于管理CT患者至关重要.
研究的目的:
- 在一个大型的法国队伍中监测先天性毒素菌的长期眼睛预后.
- 分析眼睛表现的变化随着时间的推移.
- 评估产前查和治疗对眼部结果的影响.
主要方法:
- 在1987年至2021年间,对646名被诊断为CT的儿童进行了长达35年的未来随访.
- 使用可克斯模型的灵活扩展进行统计分析,以评估受孕期对视网膜炎风险的影响.
- 随着时间的推移,视网膜炎发病率的估计.
主要成果:
- 29%的患者患上了视网炎,通常在5,7岁和12岁开始发病.
- 早期的孕产妇感染和出生时的非细胞性症状增加了视网膜炎的风险.
- 产后CT诊断延迟与眼部病变风险降低有关.
结论:
- 尽管进行查和治疗,但视网膜炎仍然是先天性毒素症患者的一个重大问题.
- 眼部表现可以发生在整个成年期,在童年和青春期达到顶峰.
- 建议对CT患者进行定期的终身眼科随访.
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