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为接受试管婴儿的夫妇提供混合预孕生活方式计划:多中心随机对照试验的经验教训

Tessy Boedt¹, Eline Dancet², Diane De Neubourg³

¹Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.

Human reproduction open

|March 8, 2024

概括

混合预孕生活方式计划对接受试管婴儿的夫妇没有显著改善怀孕率或生活方式因素. 由于COVID-19,该研究被提前停止,限制了它的力量,并建议需要进一步研究.

科学领域:

生殖医学生殖医学
生活方式干预措施生活方式干预
在体外受精 (IVF)

背景情况:

越来越多的证据将健康的生活方式与试管婴儿成功联系在一起.
针对IVF夫妇的基于移动的生活方式计划缺乏RCT评估.

研究的目的:

评估混合预孕生活方式计划对经历试管婴儿最初12个月的夫妇生殖和生活方式结果的影响.
将混合程序与注意力控制组进行比较.

主要方法:

一个多中心随机对照试验 (RCT),涉及211对接受试管婴儿的夫妇.
干预组除了接受标准护理外,还接受了混合生活方式计划 (移动应用程序,电话咨询).
对照组接受了标准护理以及手机治疗信息.

主要成果:

该干预措施对持续怀孕的时间没有显著影响 (HR 0.94;95% CI 0.63-1.4).
没有观察到对其他生殖或生活方式结果的显著影响.
程序的接受度中等 (6/10),但在男性 (38%) 和女性 (9%) 中,移动应用程序的使用率较低.

结论:

由于COVID-19大流行,RCT被过早停止,限制了统计能力.
调查结果表明,混合计划并没有显著改善结果,可能是由于应用程序参与度低.
需要进一步研究在试管婴儿中预孕生活方式计划的最佳干预设计和参与策略.

关键词:

在这个过程中,IVF IVF.饮食饮食饮食饮食生育能力生育能力生育能力生育能力生活方式生活方式正念是一种正念的状态.移动健康的移动健康身体活动身体活动随机对照试验是随机对照试验.

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