在的死肠炎期间,自然的内皮细胞淋巴细胞数量会增加
Shuja Majeed1, Shaimaa K Hamad1,2, Bikas R Shah1
1Department of Animal Sciences, College of Food Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH, United States.
Frontiers in immunology
|March 8, 2024
概括
在的死肠炎期间,自然内皮细胞 (IEL) 增加,这表明它对细菌感染有保护作用. 这项研究强调了它们在鸟类肠道免疫力中的重要性.
科学领域:
- 鸟类免疫学 鸟类免疫学
- 胃肠道免疫学 胃肠道免疫学
- 禽畜科学是一门学科.
背景情况:
- 皮内淋巴细胞 (IEL) 对于哺乳动物的肠道免疫是至关重要的.
- IEL亚群及其在肠道疾病中的作用尚不清楚.
- 结核性肠炎 (NE) 是家禽生产中的一个重要疾病.
研究的目的:
- 调查在死肠炎 (NE) 期间IEL种群的作用.
- 在实验性NE诱导后,描述IEL子集和基因表达的变化.
主要方法:
- 没有特定病原体 (SPF) 的被挑战了Eimeria maxima (EM) 和/或Clostridium perfringens (CP).
- 体重增加,病变得分和IEL群体在感染后的不同时间点进行了评估.
- 分析了细胞因子和Osteopontin (OPN) 的Jejunal基因表达.
主要成果:
- 同时感染的鸟类 (EM/CP) 显示出亚临床NE,体重增加减少,结肠长度缩短.
- 在EM/CP鸟类感染后1天 (dpi) 观察到自然IEL子集 (TCRαβ+,TCRγδ+,TCRneg,iCD8α) 的显著增加.
- 促炎性细胞因子 (IL-1β,IFN-γ) 和OPN表达在EM/CP鸟类的阴中升高1dpi.
结论:
- 自然IEL子集,特别是具有先天性和与先天性类似功能的子集,在的NE期间发生显著变化.
- 这些IEL群体可能在宿主对NE的反应中发挥关键作用,可能提供对C. perfringens的保护.
- 对肉IEL功能的进一步研究可以为管理家禽肠道疾病的策略提供信息.
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