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使用蛋白质几何学来优化细胞毒性和ROR1特异性T细胞参与者的细胞因子窗口

Xueyuan Zhou1, Felix Klaus Geyer2, Dominic Happel2

  • 1Drug Discovery and Development, Fuse Biotherapeutics, Woburn, MA, United States.

Frontiers in immunology
|March 8, 2024
PubMed
概括

下一代T细胞引入双特异性抗体 (TCEs) 提供了一个"细胞因子窗口",通过调节的细胞因子释放来有效杀死瘤. 这种方法在体内显示出显著的瘤生长抑制,没有不良事件,与第一代TCE不同.

关键词:
ROR1 是一个ROR1.一个T细胞参与者.这就是VHH VHH.细胞因子释放综合征 细胞因子释放综合征细胞毒性的脱.

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