在低出生体重儿童和青少年的2型炎症性疾病和神经发育障碍之间的关联
Hengye Huang1, Kelvin Pengyuan Zhang1,2, Karol Kexin Sun1,3
1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
2型炎症 (T2) 疾病与自闭症谱系障碍 (ASD),注意力缺陷多动症障碍 (ADHD) 和低出生体重 (LBW) 儿童的学习障碍 (LD) 风险增加有关. 这些关联因性别和种族而异.
科学领域:
- 儿科健康 儿科健康
- 免疫学 免疫学 免疫学
- 神经发育障碍 神经发育障碍
背景情况:
- 2型炎症性疾病 (T2) 越来越多地得到认可,但它们与低出生体重 (LBW) 婴儿中各种神经发育障碍的综合关联仍未得到充分研究.
- 现有证据强调了特定的神经发育条件与T2疾病之间的联系,但缺乏更广泛的理解.
研究的目的:
- 研究T2疾病与四种关键神经发育障碍之间的关联:智力障碍 (ID),自闭症谱系障碍 (ASD),注意力缺陷多动障碍 (ADHD) 和学习障碍 (LD).
- 分析这些关联,特别是在LBW儿童和青少年的群体内.
主要方法:
- 利用了2005-2018年国家卫生访谈调查的数据,重点关注3至17岁的LBW儿童.
- 采用多重加权后勤回归来评估T2疾病 (喘,亚托皮炎) 和神经发育障碍之间的关系,调整为人口统计 covariates.
- 根据年龄,性别和种族进行分组分析,以探索差异性关联.
主要成果:
- 分析了11,260名LBW儿童的队列,其中3,191人有T2疾病史.
- 在T2病史中,ID (OR 1.35),ASD (OR 1.47),ADHD (OR 1.81) 和LD (OR 1.74) 的几率增加.
- 在T2疾病和有关性别和种族的神经发育障碍之间观察到显著的相互作用,但不是年龄.
结论:
- 在LBW儿童中,T2疾病与ASD,ADHD和LD之间存在显著的关联,独立于人口因素.
- T2疾病和神经发育障碍之间的关系是由性别和种族调节的,这表明不同的生物或环境途径.
- 需要进一步的研究来确定因果关系,并阐明在LBW人群中关联T2疾病和神经发育结果的潜在机制.
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