白色和红色加工形式的人参:人参酸和心脏副作用
Jiexin Zhou1, Jiarui Zhang1, Pu Jing1
1Shanghai Food Safety and Engineering Technology Research Center, Bor S. Luh Food Safety Research Center, Key Lab of Urban Agriculture Ministry of Agriculture, School of Agriculture & Biology Shanghai Jiao Tong University Shanghai China.
Food science & nutrition
|March 8, 2024
概括
红人参 (RG) 和白人参 (WG) 具有不同的人参化物特征. 虽然两者都可能导致轻度心脏损伤,并增加大鼠的收缩性,但RG对心脏功能的影响小于WG.
科学领域:
- 药理学 药理学是指药理学的学科.
- 心血管生物学 心血管生物学
- 自然产品 化学 化学
背景情况:
- 人参 (Panax人参) 是东亚传统的药用和功能性食品.
- 白人参 (WG) 和红人参 (RG) 在加工和潜在的人参化物成分上有所不同.
- 了解这些差异对于评估它们的生理影响至关重要.
研究的目的:
- 为了比较WG和RG的金氏化物概况.
- 评估WG和RG对健康大鼠心脏的生物学影响.
- 调查对心脏功能,组织学和信号通路的影响.
主要方法:
- 超高性能液体染色学-并联质谱学 (UPLC-MS/MS) 用于人参化物分析.
- 电心电图和生物化学测试以评估心脏功能和损伤标志物.
- 心脏组织组织学和分析 (Ca2+) 信号通路 (p-CaMKII,PPARδ,SERCA2a).
主要成果:
- 与WG相比,RG表现出较高的总金色化物含量 (1.8倍) 和独特的形状,在每一种中都发现了独特的金色化物.
- 无论是WG和RG治疗都没有显著改变心电图或心脏组织学.
- 轻度心脏损伤是由心脏原蛋白和肌酸激酶水平的增加所暗示的;然而,RG显示的效果小于WG.
结论:
- RG和WG具有不同的人参化物成分,其中RG的低极性人参化物比例较高.
- 在健康的老鼠中,WG和RG都可能诱导轻度心脏损伤并改变心脏收缩信号通路.
- 在这项研究中,RG与WG相比,似乎对心脏的影响不那么明显.
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