在动物中,从蜂中获得的异桑摩尔的组织分布和药理动力学
1Department of Food Science, Graduate School of Technology, Industrial and Social Sciences Tokushima University Tokushima Japan.
来自蜂的前类黄 (Isoxanthohumol,IXA) 很快被吸收,并分布到各种组织中,主要是肝脏. 这表明作为营养药的潜在健康益处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 营养学科学 营养学科学
- 生物化学 生物化学
背景情况:
- 在水果和蔬菜中发现的 Prenylflavonoids,如异氧桑托醇 (IXA) 和 8-prenylnaringenin (8-PN),表现出有益的生物活性.
- 这些活动包括抗癌性质和抑制胰岛素抵抗,突出其潜在的健康益处.
- 然而,IXA的药理动力学特征和组织分布仍然不清楚,这限制了我们对其全身可用性的理解.
研究的目的:
- 在小鼠中研究口服的异丁醇 (IXA) 的组织分布动态.
- 为了比较IXA在单次和多次口服后的药理学特征.
- 评估IXA及其衍生物8-PN在组织中的剂量依赖积累.
主要方法:
- 高纯度异丁醇 (>90%) 被口服给小鼠,每天单剂量 (50 mg/kg) 和多剂量 (30 mg/kg 14 天).
- 使用高压液态色谱 (HPLC) 分析了组织分布.
- 肝脏积累进一步研究在老鼠每天治疗28天与不同的IXA度 (112.5-1500毫克/体重).
主要成果:
- IXA被迅速吸收,在一次剂量后的0.5小时内达到最大血度 (Cmax).
- 肝脏显示了IXA的最高度,其次是脏,胸腺,脏,肺和大脑14天后的管理.
- 在老鼠中,IXA在肝脏中的积累是剂量依赖的,而8-PN的积累与摄入时间相关,而不是量.
结论:
- 口服的IXA分布在各种组织中,肝脏的偏好显著.
- IXA及其衍生物8-PN在摄入后长达24小时的组织中被检测到.
- 这些发现表明,口服IXA可能由于其组织分布特征而作为营养药提供健康益处.
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