在COVID-19患者中高剂量维生素D补充:随机对照试验的元分析
Zhaoshuang Zhong1, Long Zhao1, Yan Zhao1
1Department of Respiratory Central Hospital, Shenyang Medical College Shenyang China.
Food science & nutrition
|March 8, 2024
概括
高剂量维生素D补充剂并没有改善COVID-19患者的死亡率或重症监护室的入院情况. 这一元分析发现高剂量的维生素D是安全的,但对改善COVID-19临床结果无效.
科学领域:
- 临床医学 临床医学
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 研究了维生素D在免疫功能中的作用及其对COVID-19结果的潜在影响.
- 关于高剂量维生素D补充剂在治疗COVID-19患者中的有效性仍然存在不确定性.
研究的目的:
- 评估高剂量维生素D补充剂在改善COVID-19诊断患者的临床结果方面的有效性.
- 评估高剂量维生素D对COVID-19患者死亡率和重症监护室 (ICU) 入院率的影响.
主要方法:
- 在PubMed,EMBASE,Cochrane图书馆和ISI Web of Science进行了系统的文献搜索,截至2022年8月.
- 包括随机对照试验 (RCT) 研究COVID-19患者高剂量维生素D (≥100,000 IU单次或≥10,000 IU每天).
- 用风险比率 (RR) 和加权平均差异 (WMD) 使用95%置信区间 (CI) 进行了元分析.
主要成果:
- 分析包括5个RCT,涉及834名患者.
- 高剂量维生素D补充剂对死亡率 (RR 1.092,95% CI 0.685-1.742) 或ICU入院 (RR 0.707,95% CI 0.454-1.102) 没有显著影响.
- 包括维生素D缺乏症患者在内的小组分析也显示没有显著的益处.
结论:
- 高剂量的维生素D补充剂对于改善COVID-19患者的临床结果,如死亡率或ICU入院,是无效的.
- 补充剂被发现是安全的和耐受良好的.
- 进一步的研究可能是必要的,以充分了解维生素D在COVID-19管理中的作用,尽管目前的证据表明高剂量没有益处.
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