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植物性饮食模式和食道癌症风险:一项跨越17年的前性队列研究
Xiaorui Zhang1, Feifan He2, Jiayue Li2
1Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100069, China.
概括
一种健康的植物性饮食可以显著降低食道癌 (EC) 风险. 相反,不健康的植物性饮食模式增加了EC风险,强调了饮食质量在癌症预防中的重要性.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 植物性饮食提供了许多健康益处,特别是在预防癌症方面.
- 关于植物性饮食模式与食道癌 (EC) 风险之间的特定关联的研究有限.
研究的目的:
- 调查三种不同的植物性饮食指数与患食道癌症的风险之间的潜在关联.
- 为了确定是否坚持健康或不健康的植物性饮食模式会影响EC风险.
主要方法:
- 来自中国高风险EC地区的15184名参与者的队列被跟踪了20多年.
- 用总体植物性饮食指数 (PDI),健康植物性饮食指数 (hPDI) 和不健康植物性饮食指数 (uPDI) 评估饮食模式.
- 考克斯比例危险回归模型用于计算EC风险的危险比率 (HR) 和95%置信区间 (95%CI).
主要成果:
- 对健康植物性饮食指数 (hPDI) 的更高坚持与显著降低EC风险有关 (HR=0.50;95% CI,0.32-0.77).
- 每增加10个点的hPDI得分与EC风险下降58%相关 (HR=0.42;95% CI,0.27-0.66).
- 相反,较高的不健康植物性饮食指数 (uPDI) 与EC风险增加有关 (HR=1.80;95% CI,1.16-2.82).
结论:
- 健康,高质量的植物性饮食模式与食道癌的风险降低有关.
- 强调植物性食品的饮食选择对于欧盟预防策略至关重要.
- 进一步的研究应该集中在植物性饮食的特定成分上,这些成分会产生对EC的保护作用.
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