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Updated: Jun 17, 2026

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介素-18结合蛋白 (IL-18BP):从发现到临床应用的漫长旅程

Soohyun Kim1,2, Hyeon Yu2, Tania Azam3

  • 1College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.

Immune network
|March 8, 2024
PubMed
概括

介素-18结合蛋白 (IL-18BP) 于1999年被发现,并作为一种可溶性对抗剂起作用. 重组IL-18BP (rIL-18BP) 显示强大的IL-18中和,为免疫疾病治疗提供了希望.

关键词:
自身免疫性疾病是一种自身免疫性疾病.基础研究 基础研究临床试验中的临床试验.发现了IL-18BP的发现在rIL-18BPBP中使用.

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...