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在老小鼠中,甲状腺激素状况不会改变压力过重后的心脏恢复

Helena Kerp¹, Janina Gassen¹, Susanne Camilla Grund¹

¹Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Frontiers in endocrinology

|March 8, 2024

概括

改变的甲状腺激素 (TH) 水平对心脏功能和心脏损伤的老年小鼠的重塑影响很小. 这表明老年心脏对TH压力的反应减弱,这是由于神代酶和甲状腺激素受体表达的变化造成的.

科学领域:

心血管生理学心血管生理学
内分泌学在内分泌学.
衰老的研究研究.

背景情况:

甲状腺激素 (THs) 影响心血管功能,但它们对先前存在的心脏病的影响,特别是老化,仍然不清楚.
由于高血压或大动脉狭窄等疾病的压力过载,加上衰老,是心力衰竭的关键危险因素.
了解心脏功能障碍的老年心脏中的TH敏感性对于控制心血管风险至关重要.

研究的目的:

研究甲状腺激素水平改变对老年小鼠带有压力诱导的心脏缩和功能障碍的影响.
在老年小鼠中评估心脏功能,重塑和生存,以应对甲状腺激素过量或缺乏,经过横向大动脉收缩 (TAC).

主要方法:

12个月大的小鼠接受了TAC,以诱导左心室压力过载.
在TAC后4周内,小鼠接受T4 (甲状腺素) 或抗甲状腺药物治疗.
分析了心脏功能,重塑标记 (壁厚,心脏重量,心肌细胞大小,细胞亡,纤维化),死亡率和基因表达 (二氧化酶,TH受体).

主要成果:

甲状腺激素的过量或缺乏对TAC后老年小鼠的心脏功能,重塑和死亡率的影响很小.
这些发现与在接受类似条件的年轻小鼠中观察到的显著影响形成鲜明对比.
老年小鼠表现出TRα2和Dio3的更高表达,并减少了Dio2,可能会降低心脏TH的可用性和作用.

结论:

改变甲状腺激素的可用性对先前存在压力诱导心脏损伤的老年小鼠的心脏功能和重塑的影响有限.
这种减弱的反应很可能是由于老年心脏中神酶和甲状腺激素受体异型的表达变化.
尽管随着年龄的增长心血管风险增加,但对甲状腺激素压力的心血管反应可能会随着年龄的增长而减弱.

关键词:

老化的老化衰老的老化脱氧化的使用方法心脏衰竭是因为心脏衰竭.不适应性心脏过度增大压力过载的压力过载.甲状腺激素是甲状腺激素的一种.甲状腺激素受体是甲状腺激素受体.横向的大动脉收缩

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