在产前暴露于多化二乙烯和注意力不集中/多动症症状中期到晚期青少年
Seonyoung Park1,2, Whitney Cowell3, Amy E Margolis4
1Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States.
Frontiers in epidemiology
|March 8, 2024
概括
产前暴露于多二乙烯 (PBDE) 可能会增加青少年女孩的注意力缺陷/多动症 (ADHD) 症状,但不是男孩. 这突显了环境毒素对神经发育的潜在性别特异性影响.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 儿科流行病学 儿科流行病学
背景情况:
- 产前暴露于多二乙烯 (PBDE) 与儿童和青春期早期注意力缺陷/多动症 (ADHD) 症状有关.
- 关于青春期内暴露于PBDE的长期影响以及这些关联中潜在的性别特异性差异的数据有限.
研究的目的:
- 调查产前PBDE暴露与从青春期中期到晚期的多动症症状之间的关联.
- 检查产前PBDE暴露与ADHD症状之间的关系的性别特异性.
主要方法:
- 从219名非洲裔美国人和多米尼加儿童的出生队伍中利用了带血PBDE度和ADHD评分表-IV (ADHD-RS-IV) 评分.
- 使用通用估计方程来分析重复的ADHD-RS得分,并使用分层模型和交叉产品术语检查性别相互作用.
主要成果:
- 产前PBDE暴露与家长报告的ADHD症状之间的关联因性别而异.
- 从性别分层分析中观察到,在女孩的产前PBDE暴露和ADHD症状之间存在积极的关系,但在男孩中没有.
结论:
- 产前PBDE暴露可能会影响中到晚青春期的ADHD症状,在女孩身上观察到明显的性别特异效应.
- 需要对更大,更多样化的样本进行进一步的研究,以证实这些关于PBDE对神经发育的长期,性别特异性影响的发现.
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