动脉样硬化早期心力衰竭多民族研究研究:理由,设计和基线特征
Lauren Beussink-Nelson1, Benjamin H Freed1, Julio A Chirinos2
1Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (L.B.-N., B.H.F., M.H., J.P., S.J.S.).
Circulation. Heart failure
|March 8, 2024
概括
在MESA早期HF研究中,使用先进的成像和生物标志物评估了老年人早期心力衰竭 (HF). 它强调了高频风险因素的高流行率,并为了解早期高频发育提供了宝贵的资源.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 生物标志物 生物标志物
背景情况:
- 目前的心力衰竭 (HF) 患病率依赖于自我报告或住院,错过了早期,未被诊断的阶段.
- 在住院治疗之前,还需要定义早期的症状性HF患病率和病原体.
研究的目的:
- 在一个多样化的队列中确定早期HF的流行率.
- 调查从风险因素过渡到早期高频率.
- 在老年人中特征早期HF表型.
主要方法:
- 动脉样硬化多民族研究 (MESA) 早期动脉样硬化研究招募了3285名参与者.
- 综合性评估包括斑点跟踪回声心脏学,堪萨斯城心肌病问卷,6分钟步行测试,动脉硬和蛋白质组学 (包括NT-proBNP).
- 报告说,回声心脏图和被动腿部升高测量具有很高的可行性.
主要成果:
- 队列中位年龄为73岁,高风险因素的流行率:高血压 (61.9%),吸烟 (53.7%),肥胖 (34.8%),糖尿病 (24.7%) 和慢性病 (22%).
- 开放性心血管疾病的患病率从2.1% (HF) 到13.6% (心房动) 之间.
- 从高比例的参与者中收集了详细的心声回声和蛋白质组数据.
结论:
- MESA早期HF研究为心血管研究人员提供了丰富的数据集.
- 它是改善早期高频率的流行病学和表型特征的关键资源.
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