可注射的自然衍生的巨孔性阿帕骨水泥作为潜在的状骨替代品
Vimal Kumar Dewangan1,2, T S Sampath Kumar1, Mukesh Doble2,3
1Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai, India.
概括
来自蛋和鱼骨的新型骨水泥显示了用于骨科应用的改进性质. 这种天然的 apatite 骨质水泥 (FBDEAp) 提供了增强的细胞活性和再吸收性,使其成为一个有前途的椎骨替代品.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 材料化学 材料化学
背景情况:
- 骨缺陷带来了重大的临床挑战,需要先进的骨移植替代品.
- 目前的合成骨水泥在生物相容性和整合方面存在局限性.
- 自然资源为骨再生提供了可持续和潜在的优质替代品.
研究的目的:
- 使用自然来源 (蛋和鱼骨) 制造一种新型的阿帕骨水泥.
- 评估开发的骨水泥的物理化学,机械和生物特性.
- 评估其作为骨架骨替代品在骨科应用中的潜力.
主要方法:
- 来自鱼骨的酸和来自蛋的酸被合成和混合.
- 一个含有生物聚合物 (凝,奇托) 和聚酸盐的液态相被用于水泥制备.
- 描述包括X射线衍射,FTIR,SEM,微CT,压力强度测试,以及体外细胞研究 (MG63细胞).
主要成果:
- 来自鱼骨和蛋的阿帕骨水泥 (FBDEAp) 呈现出临床上可接受的定时间和可注射性.
- FBDEAp表现出良好的压力强度 (5-7 MPa),可再吸收性 (12周内28%) 和相互连接的宏性 (50-400μm).
- 与合成对照相比,观察到显著增强的MG63细胞活力 (>125%),粘附,增殖和骨质基因表达 (5-13折).
结论:
- 来自天然蛋和鱼骨的FBDEAp骨,具有有利的物理化学和机械性能.
- FBDEAp表现出极好的生物相容性和骨质诱导潜力,促进细胞生长和分化.
- 这种天然衍生出来的阿帕酸骨水泥是椎骨缺陷在骨科中修复的有希望的候选者.
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