在帕金森病中皮质宏观和微观结构的变化与可能的快速眼动 睡眠行为障碍 睡眠行为障碍
Jèssica Pardo1,2, Victor Montal3,4, Anna Campabadal1,5
1Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
概括
皮层平均扩散度 (cMD) 在帕金森病 (PD) 与快速眼动睡眠行为障碍 (RBD) (PD-pRBD) 中检测到微妙的大脑变化,比皮层厚度 (CTh) 更有效. 这种成像生物标志物有助于研究PD的早期皮质变化.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 神经学 神经学
背景情况:
- 帕金森病 (PD) 中皮质缩模式与可能的快速眼动睡眠行为障碍 (RBD) (PD-pRBD) 尚不清楚.
- 皮质平均扩散度 (cMD) 是一种对皮质微结构变化敏感的新型成像生物标志物,但其在PD-pRBD中的实用性尚未先前研究.
研究的目的:
- 研究cMD作为对PD-pRBD微妙皮质微观结构变化的敏感指标.
- 检查PD-pRBD中cMD和皮层厚度 (CTh) 之间的关系.
主要方法:
- 在22名PD-pRBD患者中比较cMD和CTh,31名PD没有可能的RBD患者 (PD-nonpRBD) 和28名健康对照 (HC) 使用3T MRI和神经心理测试.
- 使用一般线性模型进行群组比较 (P < 0.05) 并计算了科恩的d效应大小.
主要成果:
- 与PD-non-pRBD患者相比,PD-pRBD患者在几个皮质区域表现出明显更高的cMD,其中CTh没有显著差异.
- 与HC相比,PD-pRBD患者的双边后部cMD增加,其中部分CTh发现重叠.
- PD-nonpRBD患者与HCs没有表现出cMD差异,但在特定区域表现出皮质稀释.
结论:
- 在揭示PD亚组之间的显著皮质结构差异方面,cMD似乎比CTh更敏感.
- cMD是研究帕金森病早期皮质变化的有价值的成像生物标志物.
- 这些发现突显了cMD在区分PD亚型和监测疾病进展方面的潜力.
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