相关实验视频

Updated: Jul 1, 2025

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects

Published on: June 30, 2017

热响应凝式过热限制器启用智能光热疗法

Yanji Chu¹, Qianci Wang², Shanzhi Lyu³

¹Key Laboratory of Advanced Light Conversion Materials and Biophotonics, Department of Chemistry, Renmin University of China, Beijing, 100872, China.

Small (Weinheim an der Bergstrasse, Germany)

|March 8, 2024

概括

智能冷却热响应凝可以防止光热疗法 (PTT) 期间过热. 这种新型材料通过稳定温度来提高安全性,保护正常组织免受热损伤.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
医学物理医学物理

背景情况:

光热疗法 (PTT) 面临的局限性是由于不受控制的高温导致健康组织的热损伤.
开发安全有效的PTT需要精确的热调节,以防止副作用.

研究的目的:

开发一种智能冷却热响应 (ICTR) 凝,用于PTT中的受控光热加热.
调查ICTR凝在PTT期间防止周围组织受到热损伤的能力.

主要方法:

合成了一种ICTR凝,其中包含了聚N-异烯胺-协烯胺 (P(NIPAM-AM)) 微凝.
评估了凝的光学和热性能,重点关注近红外 (NIR) 光传导率和温度依赖的折射率变化.
进行了动物研究,以评估与传统PTT相比,ICTR凝激活PTT的疗效和安全性.

主要成果:

在低温下,ICTR凝具有高的NIR透射率 (>95%) 并在特定值以上增加光散射.
通过ICTR凝进行负反调节,使病变温度稳定在45°C左右,同时保持皮肤表面温度低于35°C.
组织学分析显示,与传统PTT不同,ICTR凝启用PTT治疗的皮肤组织没有受到热损伤.

结论:

ICTR凝为PTT提供了一个智能热调节机制,提高了安全性和有效性.
这种方法建立了控制PTT温度的通用范式,最大限度地减少意外伤害.
基于ICTR凝的PTT具有更安全,更有效的治疗应用的巨大潜力.

关键词:

P ((NIPAM-AM) 微凝) 的使用情况.光散射的光散射是一种散射.过热限制器过热限制器光热疗法是一种光热疗法.热敏的高分子聚合物

更多相关视频

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

相关概念视频

Decreased Body Temperature

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...

Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...