剩余胆固醇在动脉样硬化心血管疾病中的预测效用
Spencer D Proctor1, Maggie Wang1, Donna F Vine1
1Metabolic and Cardiovascular Diseases Laboratory, Division of Nutrition, University of Alberta.
Current opinion in cardiology
|March 8, 2024
概括
剩余胆固醇 (RC) 与动脉样硬化心血管疾病 (ASVD) 有因果关系. 减少一生中RC可能会显著降低ASVD风险,这表明它应该成为查和治疗目标.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 剩余胆固醇 (RC) 源自基洛米克朗和非常低密度脂蛋白的代谢.
- 越来越多的证据将RC与动脉样硬化心血管疾病 (ASVD) 联系起来,提供了超越LDL胆固醇 (LDL-C) 的见解.
- 在残留心血管风险中RC的作用需要进一步研究以获得临床应用.
研究的目的:
- 审查了解RC在动脉动脉生成中的作用的最新进展.
- 为了验证RC作为ASVD的预测因素.
- 讨论RC在心血管风险评估和管理中的临床影响.
主要方法:
- 对前性和后性队列研究的分析.
- 包括来自大型门德尔随机化研究的数据.
- 对RC与ASVD相关的现有证据的综合.
主要成果:
- 已经证实了RC和ASVD之间的显著因果关系,独立于LDL-C.
- 门德尔随机化研究证实RC是动脉样硬化事件风险的主要驱动因素.
- RC水平独立地与各种形式的ASVD有关.
结论:
- 终身降低RC与大幅降低ASVD风险有关.
- 目前的指导方针应该修订,以包括RC作为一个独立的ASVD风险因素.
- 建议早期进行RC查和开发RC降低疗法.
相关概念视频
Cholesterol: Significance and Regulation
544
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
544
Blood Studies for Cardiovascular System III: Serum Lipid Profile
163
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
163
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
91
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
91
Lipids: Dietary Sources and Requirements
735
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
735
Inflammation
53.4K
Overview
53.4K
Lipid-derived Compounds in the Human Body
4.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.4K


