一项三臂随机对照研究,比较了1型糖尿病患者使用连续皮下胰岛素输液或多次每日注射的患者报告的结果
Katharine Barnard-Kelly1,2, Florian Thienel3, Julia K Mader4
1Southern Health NHS Foundation Trust, Calmore, UK.
Journal of diabetes science and technology
|March 8, 2024
概括
从每天多次注射 (MDI) 转换为持续皮下胰岛素输注 (CSII) 治疗显著改善了患者报告的结果和1型糖尿病的血糖控制. 两种补丁系统都表现出可比的有效性,没有观察到它们之间的实质差异.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病 技术 技术
背景情况:
- 1型糖尿病的管理通常涉及每天多次注射 (MDI) 或连续皮下胰岛素输注 (CSII).
- 胰岛素补丁提供了一个替代的CSII输送方法.
- 患者报告的结果 (PROs) 对于评估糖尿病治疗的有效性至关重要.
研究的目的:
- 用两种不同的胰岛素补丁系统与MDI相比,对1型糖尿病患者进行PRO比较.
- 评估从MDI切换到CSII对患者福祉和血糖控制的影响.
- 评估新型胰岛素补丁系统的性能,与已有的系统和MDI相比.
主要方法:
- 一个随机的三臂研究,涉及181名1型糖尿病患者.
- 参与者被分配给MDI,Accu-Chek Solo微型 (Solo) 或Omnipod,持续26周.
- 使用糖尿病技术问卷 (DTQ) 测量了PROs;还监测了HbA1c水平.
主要成果:
- 在26周后,Solo组的DTQ得分明显高于MDI组的DTQ得分 (P = .001).
- 在Solo和Omnipod组之间没有发现DTQ得分的显著差异 (P = .382).
- 在CSII组中,HbA1c水平降低了 (Solo: -0.2%,Omnipod: -0.1%),而在MDI组中略有增加 (0.2%);Solo和MDI之间的差异很大 (P = .009).
结论:
- 从MDI切换到CSII治疗可以改善1型糖尿病的心理健康和生理结果.
- 在Accu-Chek Solo微型和Omnipod补丁系统中,它们的效率是可比的.
- 特别是用补丁进行的CSII疗法,是MDI治疗1型糖尿病的可行替代方案.
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