从童年肥胖症到右心脏生理学和肺循环的因果途径的特征使用终身孟德尔随机化
Genevieve M Leyden1,2, Helena Urquijo1, Alun D Hughes3
1MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol Bristol UK.
Journal of the American Heart Association
|March 8, 2024
概括
儿童肥胖直接影响成人心脏结构,特别是右心脏. 其他心血管影响与整个生命中的身体组成有关,而不仅仅是儿童体重.
科学领域:
- 心血管健康 心血管健康
- 儿童肥胖症 儿童肥胖症
- 遗传学和流行病学
背景情况:
- 童年肥胖与晚年心脏变化有关.
- 建立直接的因果关系是具有挑战性的,因为混生命过程的身体成分因素.
研究的目的:
- 调查儿童体型对成年人心血管结构和功能的直接因果关系.
- 为了区分童年肥胖的影响与其他生命过程中的身体组成措施.
主要方法:
- 使用生命历程 门德尔随机化,人类遗传学的因果推断技术.
- 评估了童年身体大小对右心脏和肺循环的11项措施的独立影响.
- 在整个生命过程中控制其他人类学特征.
主要成果:
- 强有力的证据表明,儿童的身体大小直接导致成年后右心脏结构扩大 (例如,右心室末端透气体积).
- 儿童身体尺寸对上升性大动脉直径的影响是由成人身体尺寸解释的.
- 对肺动脉特征和右心房功能的影响分别受到成年无脂肪质量和儿童身高的影响.
结论:
- 儿童体型对成年人右心脏结构有持久的直接影响.
- 其他心血管疾病的相关性更可能是由于不同生命阶段的身体组成.
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