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尽管进行了全身和局部治疗,但仍然存在持久和严重的mpox角质炎
Laura Domínguez García1, Almudena Gutierrez-Arroyo2, Rosa Miguel-Buckley3
1Department of Ophthalmology, La Paz University Hospital, Madrid, Spain.
Cornea
|March 8, 2024
概括
莫波克斯病毒可以导致持续的眼睛炎症,包括外周性角膜炎,即使在免疫能力强的个体. 早期使用皮质类固醇可能会恶化mopox角质炎的结果,强调需要用PCR进行仔细监测.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 麻疹病毒感染可能会出现眼部表现.
- 外周性角膜炎 (PUK) 是角膜的严重炎症状况.
研究的目的:
- 报告一个与mopox相关的外周性角膜炎病例.
- 突出MPOX炎的诊断和管理挑战.
主要方法:
- 一个具有免疫能力的男性患有粘膜皮肤mopox的病例报告.
- 通过角膜聚合酶链反应 (PCR) 和培养证实mopox角质炎的诊断.
- 记录的临床过程和治疗干预措施.
主要成果:
- 患者患有严重的PUK,并患有持续的角膜上皮缺陷,四肢炎,内皮炎和神经变.
- 角膜炎症持续超过6个月,尽管多次抗病毒治疗 (trifluorothymidine,tecovirimat,cidofovir).
- 阳性角膜PCR结果与持续的炎症相关.
结论:
- 姆波克斯病毒可以导致长时间的眼睛炎症和免疫能力强的主体的复制.
- 以前的局部皮质类固醇使用可能会加剧mopox角质炎的严重程度和持续时间.
- 来自PCR的循环值可以帮助诊断和治疗监测.
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