周围动脉疾病:在家族性高胆固醇血症中被低诊断的疾病? 一个系统的审查
Elisa Acitelli1, Alexis F Guedon2, Sara De Liguori1
1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Endocrine
|March 8, 2024
概括
家庭性高胆固醇血症 (FH) 患者表现出广泛的外周动脉疾病 (PAD) 患病率和发病率. 需要更多的研究来了解FH中的PAD,特别是新的降脂治疗.
科学领域:
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 家族性高胆固醇血症 (FH) 是一种常见的遗传性疾病,导致高的LDL胆固醇和早期动脉样硬化.
- 虽然FH与冠状动脉和动脉疾病有关,但其与外周动脉疾病 (PAD) 的关联不太清楚.
研究的目的:
- 系统地审查有关FH患者PAD流行率和发病率的现有证据.
- 确定FH人口中关于PAD的研究缺口.
主要方法:
- 在MEDLINE和Embase数据库 (2013-2023) 上进行了全面的文献搜索.
- 包括评估FH患者PAD患病率和发病率的研究;评论,病例报告和非英语文章被排除在外.
主要成果:
- 分析包括了24项研究,其中19项报告了PAD患病率,5项报告了PAD发生率.
- PAD患病率在0.3%至60%之间,发病率在0.5%至4.2%之间,这可能是由于PAD定义不同.
结论:
- 在FH患者中对PAD的研究有限.
- 进一步的研究对于了解FH的外周血管疾病和优化患者管理至关重要,特别是新兴的降脂疗法.
相关概念视频
Cholesterol: Significance and Regulation
544
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
544
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
661
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
661
Blood Studies for Cardiovascular System III: Serum Lipid Profile
163
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
163
Ischemic Heart Disease: Overview
1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K


