炎症和免疫系统对肝细胞癌在肝切除术后复发的影响
Sha She1, Jinzhi Shi1, Jiling Zhu1
1Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Cancer medicine
|March 8, 2024
概括
手术后肝细胞癌 (HCC) 的复发率很高 (50-70%). 本综述详细介绍了预测复发的炎症和免疫标志物,指导辅助治疗以改善HCC患者的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 肝细胞癌 (HCC) 是全球主要的癌症杀手.
- 肝切除术是可切除的HCC的主要治疗方法,但5年复发率在50%到70%之间.
研究的目的:
- 审查预测HCC切除后复发的炎症和免疫标志物.
- 为指导旨在减少HCC复发的辅助治疗策略.
主要方法:
- 对瘤微环境,炎症和HCC复发中的免疫标志物研究的文献综述.
- 分析既有和新兴的预测标记物,如中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR).
主要成果:
- 瘤微环境因素,包括全身炎症和免疫调节,显著影响HCC复发.
- 特定的标记物如NLR,PLR,细胞毒性T细胞和调控性T细胞与术后复发风险有关.
结论:
- 炎症和免疫标志物对于预测肝切除术后HCC复发至关重要.
- 了解这些标志物可以为个性化辅助疗法提供信息,以改善患者的生存率和减少复发率.
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