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胃神经内分泌瘤的临床病理学特征:全面分析

Mengli Zi^1,2,3,4, Yubo Ma^2,3,4,5, Jinxia Chen^1,2,3,4

¹Postgraduate training base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.

Cancer medicine

|March 8, 2024

概括

胃神经内分泌癌/混合神经内分泌与非神经内分泌瘤 (g-NEC/MiNEN) 的预后比其他胃癌更差,但受益于辅助治疗. 这一发现对于理解g-NEN和改善患者治疗结果至关重要.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

胃神经内分泌瘤 (g-NENs) 代表了一组多样化的瘤,具有不同的临床行为.
了解不同g-NEN亚型的特定临床病理特征和预后因素对于有效的患者管理至关重要.

研究的目的:

研究胃神经内分泌瘤 (g-NENs) 的临床病理学特征.
评估g-NENs的预后影响,特别是比较胃神经内分泌癌/混合神经内分泌与非神经内分泌瘤 (g-NEC/MiNEN) 与其他胃恶性瘤.

主要方法:

在2007年至2021年间诊断出g-NEN的142名患者的回顾性分析.
对g-NEN亚型和其他胃癌,如胃腺癌 (GAC) 和结环细胞癌 (SRCC) 之间的临床病理特征和生存率的比较.

主要成果:

胃神经内分泌癌/混合神经内分泌与非神经内分泌瘤 (g-NEC/MiNEN) 与胃神经内分泌瘤 (g-NET) (p < 0.001) 和胃腺癌 (GAC) (p < 0.001) 相比,预后明显较差.
在差异化不良的GAC中,g-NEC/MiNEN也显示出更糟糕的预后 (p = 0.007).
接受术后辅助治疗的g-NEC/MiNEN患者的整体存活时间 (OS) 显著延长 (p = 0.010).

结论:

对于g-NEC/MiNEN的预后比g-NET,GAC和差异化GAC.的预后更差.
术后辅助疗法为患有g-NEC/MiNEN的患者提供了生存益处.

关键词:

胃混合的神经内分泌-非神经内分泌瘤.胃神经内分泌癌瘤是胃神经内分泌癌.胃神经内分泌新生体胃神经内分泌新生体胃神经内分泌瘤胃神经内分泌瘤病理特征病理特征病理特征预后预后预后

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