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Updated: Jul 7, 2026

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
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分子特征的识别定义了诱导脊髓和骨运动神经元中的差异性蛋白质稳定反应

Ana Paula Zen Petisco Fiore1, Shuvadeep Maity2, Lauren Jeffery1

  • 1New York University, Department of Biology, New York, NY 10003, USA.

Cell reports
|March 8, 2024
PubMed
概括

头骨运动神经元比脊髓运动神经元更好地在蛋白质毒性压力下生存,因为它们通过升高调节支持蛋白质稳定和内质网膜功能的蛋白质. 这项研究揭示了与ALS等神经退行性疾病相关的蛋白质稳定机制的细胞类型特异性差异.

关键词:
CP: 细胞生物学 细胞生物学科普:神经科学:神经科学是什么?在Ublcp1中使用.骨髓缩侧面硬化症 (ALS) 是一种运动神经元 运动神经元蛋白质酶体蛋白质酶体是如何形成的不折叠的蛋白质反应反应

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