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Updated: Jul 1, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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长读测序用于快速和可靠地识别正确的基因组编辑等位基因:基于PCR和Cas9捕获方法

Christopher V McCabe1, Peter D Price1, Gemma F Codner1

  • 1The Mary Lyon Centre, MRC Harwell, Oxfordshire, United Kingdom.

PLoS genetics
|March 8, 2024
PubMed
概括

长读测序有效验证了马赛克动物中复杂的CRISPR/Cas9编辑. 这种方法证实了精确的等位基因整合,克服了用于基因组编辑验证的传统测序的挑战.

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CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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