蛋白质静态调支了新型多细胞特征的演变
Kristopher Montrose1,2, Dung T Lac3, Anthony J Burnetti3
1Helsinki Institute of Life Science, HiLIFE, University of Helsinki, Helsinki, Finland.
Science advances
|March 8, 2024
概括
细胞延长,对于早期多细胞进化至关重要,是由减少的Hsp90伴侣活动驱动的. 这种适应通过改变细胞分裂和生长来增强生物体的大小和健康状况.
科学领域:
- 进化生物学 进化生物学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 多细胞性是复杂生命的基础,但其早期的分子基础仍然不太了解.
- 了解推动向多细胞性转变的遗传和分子机制是进化生物学中的一个关键挑战.
研究的目的:
- 在多细胞长期进化实验 (MuLTEE) 中研究多细胞适应的分子基础.
- 确定关键的分子参与者和参与细胞延长和生物体大小增加进化的途径.
主要方法:
- 利用多细胞长期进化实验 (MuLTEE) 来研究进化适应.
- 分析了伴侣Hsp90和循环素依赖激酶Cdc28在细胞形态和多细胞健康中的作用.
- 研究基因表达的变化及其对细胞分裂和生长动态的影响.
主要成果:
- 细胞延长的融合进化,是多细胞性的一个关键适应,是由陪伴者Hsp90.0的下调驱动的.
- Hsp90通过破坏Cdc28的稳定性来调节形态发生,从而导致延迟线粒分裂和长时间的极化细胞生长.
- 恢复Hsp90或Cdc28表达导致细胞较短,小群体,并减少多细胞适应性.
结论:
- 像Hsp90这样的古代蛋白质折叠系统可以快速调整,以在生物个性水平上推动进化创新.
- 揭示了早期多细胞进化背后的新型发育现象和分子机制.
- 证明了Hsp90-Cdc28相互作用在细胞延长和多细胞性进化的关键作用.
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