相关实验视频

Updated: Jul 1, 2025

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

发芽酵母菌的新陈代谢化综合征

Roland Tengölics^1,2,3, Balázs Szappanos^1,2,4, Michael Mülleder⁵

¹Hungarian Centre of Excellence for Molecular Medicine - Biological Research Centre Metabolic Systems Biology Lab, Szeged 6726, Hungary.

Proceedings of the National Academy of Sciences of the United States of America

|March 8, 2024

概括

细胞代谢组进化,或代谢物水平,快速变化,独立于代谢网络结构. 化对酵母代谢产生了深远的影响,推动了诸如香味产生等特征的融合进化.

科学领域:

进化生物学是进化的生物学.
代谢学代谢学代谢学
系统生物学系统生物学

背景情况:

细胞代谢是动态的,通过代谢网络结构和代谢物度的改变而演变.
代谢组包括所有代谢物水平,为细胞生理学和进化适应提供了关键的见解.

研究的目的:

研究不同酵母物种和进化时间尺度的代谢状态的进化动态,特别是代谢物水平.
确定代谢组进化与代谢网络结构变化之间的关系.
评估化对酵母代谢的影响,并确定融合进化的特征.

主要方法:

在27个芽酵母物种的9个种群中对代谢物进行基因组学分析.
代谢组变异和代谢网络结构的比较分析.
调查野生和养酵母种群之间的代谢物差异.

主要成果:

与代谢网络结构相比,代谢物水平的演变更快,更独立.
代谢变化主要是逐渐积累的,但受到养的重大影响.
在独立养的Saccharomyces cerevisiae菌群中观察到代谢的融合进化,影响中央代谢和与芳香相关的氨基酸.

结论:

代谢进化为酶谱的进化提供了补充信息.
化施加强大的选择性压力,导致酵母代谢组发生显著和反复的变化.
人类驱动的选择深刻地塑造了酵母的中央代谢和代谢物概况,使它们适应与人类相关的环境.

关键词:

这种植物是Saccharomyces cerevisiae.融合进化的趋同.化化化化代谢生物组的代谢生物组遗传学上的比较方法.

更多相关视频

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research

Published on: June 7, 2024

Analysis of the Development of a Morphological Phenotype as a Function of Protein Concentration in Budding Yeast

Analysis of the Development of a Morphological Phenotype as a Function of Protein Concentration in Budding Yeast

Published on: March 24, 2010

相关概念视频

Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...