揭示微粒系统中水友性和疏水性聚合物的潜力:加工技术的机遇和挑战
Subrat Kumar Panigrahi1, Sougat Das1, Saptarshi Majumdar1
1Department of Chemical Engineering, Indian Institute of Technology, Hyderabad, Telangana 502285, India.
Advances in colloid and interface science
|March 8, 2024
概括
可生物降解的聚合物微粒通过克服传统系统的局限性来改善药物输送. 本综述详细介绍了微粒子制备,封装因子和先进制药应用中的材料作用.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 传统的药物输送系统面临着诸如低生物可用性和不受控制的释放等挑战.
- 可生物降解的聚合物微粒作为先进的药物载体提供了一个有希望的解决方案.
- 这些微粒通过提供增强的生物可用性和受控释放配置文件来解决这些局限性.
研究的目的:
- 提供生物降解的聚合物微粒在药物输送中的全面审查.
- 探索水友性和疏水性材料对微粒子特性的影响.
- 讨论微粒制备和微封装技术的进展.
主要方法:
- 关于微粒子技术近期进展的文献综述.
- 分析影响微封装效率和药物负载的因素.
- 评估水友和疏水性材料对微粒物性能的贡献.
主要成果:
- 可生物降解的微粒显示出克服传统药物输送缺点的巨大潜力.
- 材料特性 (水友性/疏水性) 极大地影响微粒的行为和药物释放.
- 优化的微封装技术是为特定应用量身定制微粒物质的关键.
结论:
- 可生物降解的聚合物微粒是多功能载体,有可能彻底改变药物输送.
- 对微封装优化的进一步研究可以导致具有所需特征的微粒.
- 这个领域的演变有望为制药科学和患者的结果做出重大贡献.
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