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Updated: Jul 1, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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C端结合蛋白2是一种新型瘤抑制剂,向多发性髓瘤中MYC-IRF4轴

Coty Hing Yau Cheung1, Chi Keung Cheng1, Kam Tong Leung2

  • 1Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

Blood advances
|March 8, 2024
PubMed
概括

在多发性骨髓瘤中,C-终端结合蛋白2 (CTBP2) 通过抑制MYC-IRF4轴,起到瘤抑制作用. 恢复CTBP2显示出强大的抗髓瘤作用,并为这种MYC/IRF4成癌症提供了一种新的治疗策略.

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