用非小细胞肺癌患者的临床和PET数据来预测生存结果的集中和非同步联合学习方法之间的比较
Vi Thi-Tuong Vo1, Tae-Ho Shin2, Hyung-Jeong Yang1
1Department of Artificial Intelligence Convergence, Chonnam National University, Gwangju, 61186, South Korea.
Computer methods and programs in biomedicine
|March 8, 2024
概括
联合学习 (FL) 有效预测非小细胞肺癌 (NSCLC) 患者使用临床和PET数据的生存时间. 这种保护隐私的方法与集中式模型的性能相匹配,优于单个客户端的方法.
科学领域:
- 医疗信息学 医疗信息学
- 机器学习在瘤学中
- 无线电学 (Radiomics) 是一种无线电学.
背景情况:
- 生存分析对于癌症治疗决策至关重要.
- 深度学习 (DL) 显示出对生存预测的前景.
- 为DL整合多机构数据受到隐私方面的担忧的阻碍.
研究的目的:
- 提出FedSurv,一个异步联合学习 (FL) 框架用于生存时间预测.
- 整合临床信息和基于正电子发射断层扫描 (PET) 的功能,以改善预测.
- 解决医疗数据隐私挑战,开发理想的预测模型.
主要方法:
- 开发了FedSurv,一种使用DL进行生存预测的异步FL框架.
- 采用了两个数据集:RNSCLC (公共) 和CNUHH (内部) 对非小细胞肺癌 (NSCLC) 患者.
- 在分布式客户端上训练DL模型,将权重聚合到全球模型中,以提高隐私和性能.
主要成果:
- 在RNSCLC和CNUHH数据集上,FedSurv的性能与集中式方法相提并论.
- 与单个客户端模型相比,FL方法显示出更高的生存时间预测准确性.
- 在独立数据集上使用平均绝对误差 (MAE) 和C指数评估性能.
结论:
- 联合学习 (FL) 是可行且有效的,用于预测NSCLC患者的个人存活率.
- 在FL框架内整合临床和基于PET的特征可以提高预测的准确性.
- 这种保护隐私的方法有助于跨机构合作模式的发展.
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