在卵子捐赠周期中,从周期第7天起使用二二激素进行孕激素原始卵巢刺激:一项纵向研究
S Hendrickx1, M De Vos2, N De Munck1
1Brussels IVF, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Reproductive biomedicine online
|March 8, 2024
概括
使用二二激素的孕激素主导卵巢刺激 (PPOS) 协议与卵细胞检索的淋巴激素释放激素 (GnRH) 反对者协议同样有效,为捐赠者提供了显著的成本节省.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 卵巢刺激协议对于辅助生殖中卵细胞检索至关重要.
- 比较不同的刺激方案有助于优化患者的治疗结果和成本效益.
研究的目的:
- 在卵细胞捐赠者中,将孕激素原制卵巢刺激 (PPOS) 协议与丁多激素的疗效和成本与淋巴腺激素释放激素 (GnRH) 反对者协议进行比较.
主要方法:
- 从64个卵细胞捐赠者的128个周期进行了回顾性的纵向研究.
- 捐赠者接受了PPOS和GnRH抗剂协议,并使用标准化的淋巴腺素类型和剂量.
- 主要结局是检索到的累积卵细胞复合体 (COC) 的数量.
主要成果:
- 在PPOS和GnRH抗剂协议之间,获得的COC数量 (19.7与19.2) 和第II阶段卵细胞数量 (15.5与16.2) 相似.
- 刺激持续时间 (10.5 vs. 10.8天) 和淋巴腺素消耗量 (2271.9 vs. 2321.5 IU) 的比较.
- 与GnRH对抗剂协议 (€1196.4) 相比,在PPOS协议 (€898.3) 中观察到显著的成本降低.
结论:
- PPOS和GnRH抗剂协议的产量与卵细胞检索和MII卵细胞产量相似.
- PPOS协议在降低成本方面具有显著的优势.
- 在PPOS协议下没有发生过早排卵,即使在晚些时候启动孕激素.
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