小学中的结构性种族主义以及黑人和白人年轻人间表观遗传年龄加速的变化
Connor D Martz1, Aprile D Benner2, Bridget J Goosby3
1Population Research Center, The University of Texas at Austin, United States.
Social science & medicine (1982)
|March 8, 2024
概括
学校中的结构性种族主义加快了黑人年轻人的表观遗传衰老,特别是在隔离的,处于不利地位的环境中. 学校环境影响生物衰老,并可能预测未来的健康差异.
科学领域:
- 环境表观遗传学环境表观遗传学
- 发展心理学是发展心理学.
- 公共卫生 公共卫生
背景情况:
- 美国小学教育中的结构性种族主义造成不平等,对年轻人的健康和发展构成风险.
- 不利的学校环境可能通过压力介导的表观遗传路径对黑人青年产生生物学影响.
- 了解学校环境和表观遗传衰老之间的联系对于解决健康差异至关重要.
研究的目的:
- 检查儿童暴露在不利的学校环境和青春期表观遗传衰老变化之间的关联.
- 使用行政数据识别特定种族的小学背景.
- 估计不同学校类型学的表观遗传年龄加速的变化.
主要方法:
- 基于DNA甲基化的表观遗传时钟 (GrimAge,PhenoAge,DunedinPACE) 由9岁和15岁的唾液样本计算出来.
- 潜阶级分析确定了基于种族隔离,纪律,成绩,资源,劣势和骚扰的特定学校背景.
- 从童年到青春期估计表观遗传年龄加速的变化.
主要成果:
- 黑人青少年的三个学校环境:隔离/高度不利,隔离/中等不利,整合/中等不利.
- 白人青少年的两种学校环境:整合/不平等,白人占主导地位/处于优势.
- 黑人青年在隔离的,高度不利的学校显示增加了表观遗传衰老 (GrimAge,DunedinPACE).
- 在综合,中等劣势学校的黑人青年显示表观遗传衰老 (GrimAge) 的放缓.
- 在白人青年中没有发现任何显著的关联.
结论:
- 小学结构性种族主义的表现与黑人青年早期的表观遗传年龄加速有关.
- 学校环境可能会影响生物衰老的轨迹,并预测未来的健康不平等.
- 针对学校环境干预措施可以减轻不良表观遗传影响,促进健康公平.
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