副心脏脂肪组织与2型糖尿病早期结构和功能性心脏变化的关联
Sarah L Ayton1, Jian L Yeo1, Gaurav S Gulsin1
1Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
European journal of radiology
|March 8, 2024
概括
心脂肪组织 (EAT) 的体积和组成与2型糖尿病 (T2D) 中的心脏功能障碍有关. 在T2D中较高的低衰减EAT与左心室功能受损有关,这表明它在心脏健康中起着作用.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 失调的上心脂肪组织 (EAT) 与2型糖尿病 (T2D) 中心力衰竭的发展有关.
- 在没有已知的心血管疾病的T2D患者中,亚临床心脏功能障碍可能会先于明显的心力衰竭.
研究的目的:
- 调查EAT体积和组成与T2D中亚临床心脏功能障碍标志物的关联.
- 为了比较患有和没有T2D的个体之间的EAT特征和心脏功能.
主要方法:
- 未来病例控制研究包括215名T2D患者和39名没有心血管疾病的对照.
- 计算机断层扫描 (CT) 使用深度学习量化了总EAT体积,平均CT衰减和低衰减EAT体积,并将其索引为身体表面积.
- 线性回归评估了EAT指标与心磁共振衍生的左心室 (LV) 体积和全球纵向应变 (GLS) 之间的关联.
主要成果:
- 与对照组相比,T2D参与者表现出较高的LV质量/体积比率和较低的GLS.
- 在T2D患者中,低衰减指数的EAT体积显著高于T2D患者 (18.8cm2/m2对比9.4cm2/m2).
- 低衰减指数的EAT体积独立地与增加的LV质量/体积比和T2D中减少的GLS有关.
结论:
- 在T2D中增加的EAT体积与降低的平均CT衰减有关.
- 增加低衰减EAT体积是T2D患者亚临床心脏功能障碍的弱但独立的预测指标.
相关概念视频
01:36Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
01:24Obesity
498
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
498