诱发衰老的tRNAGlu衍生碎片通过准线粒体转化依赖的组织来损害谷氨酸生物合成

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Author Spotlight: Decoding Mitochondrial Aging
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Published on: June 30, 2023

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Dingfeng Li1, Xinyi Gao1, Xiaolin Ma1

  • 1Department of Neurology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230001, China; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; CAS Key Laboratory of Brain Function and Diseases, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.

Cell metabolism
|March 8, 2024
PubMed
概括

与年龄相关的小RNA (tsRNA) 在大脑线粒体中积累,扰乱了谷氨酸水平和记忆力. 减少这种tsRNA保护老年大脑,揭示了打击大脑衰老的新目标.

关键词:
血管新生素的产生大脑衰老 老龄化基督教组织是基督教组织.谷氨酸代谢 谷氨酸代谢记忆力下降 记忆力下降线粒体中的线粒体.线粒体的翻译过程由tRNA衍生的小RNAs.

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