在早期更年期后优化健康
Gita D Mishra1, Melanie C Davies2, Sarah Hillman3
1Australian Women and Girls' Health Research Centre, School of Public Health, University of Queensland, Brisbane, QLD, Australia.
Lancet (London, England)
|March 8, 2024
概括
在40至44岁之前出现的早期更年期会增加慢性疾病的风险,需要更好的临床指导. 将早期更年期视为一个范围可以改善妇女的诊断和治疗
科学领域:
- 生殖内分泌学
- 女性健康
- 临床医学
背景情况:
- 绝经通常发生在50-51岁左右.
- 早期更年期 (40至44岁) 影响全球8%至12%的女性.
- 早期的卵巢衰竭 (在40岁之前) 影响了另外2-4%的女性.
研究的目的:
- 突出与早期更年期和早产卵巢衰竭相关的健康风险.
- 解决早期更年期临床指导的差距.
- 提出一种基于频谱的方法来管理早期更年期.
主要方法:
- 对早期更年期的短期和长期后果的证据的审查.
- 制定临床诊断和管理的实用框架.
- 考虑患者的症状,年龄,病史和个人优先事项.
主要成果:
- 早期更年期和过早的卵巢衰竭与骨质疏松症和心血管疾病的风险增加有关.
- 经历过早期更年期的女性可能会面临心理压力,感觉没有支持.
- 现有的指导方针主要针对过早的卵巢衰竭, 留下早期更年期的空白.
结论:
- 早期更年期应该被视为一个连续性, 而不是严格的年龄门.
- 提供个性化管理框架以优化生活质量和健康结果.
- 建议进行进一步的研究,以解决早期更年期的现有证据缺口.
更多相关视频
06:49Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
10.9K
14:26A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
Published on: April 7, 2014
15.4K
相关概念视频
Menopause
158
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
158
Hormonal Regulation of the Menstrual Cycle
369
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
369
Hormonal Control of the Ovarian Cycle
496
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
496
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Hormonal Regulation
43.5K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.5K
Infertility in Females
292
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
292
