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相关概念视频

Menopause01:28

Menopause

158
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
158
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
358
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

369
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
369
Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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相关实验视频

Updated: Jul 1, 2025

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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在癌症后治疗更年期

Martha Hickey1, Partha Basu2, Jenifer Sassarini3

  • 1Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and the Royal Women's Hospital, Melbourne, VIC, Australia.

Lancet (London, England)
|March 8, 2024
PubMed
概括

癌症幸存者通常面临严重的更年期症状, 需要有效的治疗策略,考虑激素治疗的安全性和癌症患者的非激素选择.

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科学领域:

  • 癌症学
  • 妇科医生
  • 绝经管理

背景情况:

  • 每年有数以百万计的女性被诊断出患有癌症,
  • 改善癌症存活率导致更多的妇女经历长期治疗效应,如早产卵巢衰竭 (POI) 或早期更年期.
  • 癌症治疗引起的更年期症状往往比自然更年期更严重,可能包括性功能障碍,睡眠,情绪和生活质量受损.

研究的目的:

  • 审查癌症幸存者的更年期症状诊断和管理方面的挑战.
  • 评估更年期激素治疗 (MHT) 和癌症患者的非激素治疗的疗效和安全性.
  • 突出需要改善以患者为中心的护理模式,

主要方法:

  • 对癌症幸存者的更年期症状管理的当前文献的综述.
  • 对更年期激素治疗 (MHT) 和非激素干预措施的证据分析.
  • 对诊断挑战和护理模式进行讨论.

主要成果:

  • 在癌症幸存者的更年期症状可能是严重的,并与癌症相关的症状重叠,使诊断复杂化.
  • 对于许多癌症患者来说,MHT是有效的血管运动症状,并且通常是安全的.
  • 非荷尔蒙和非药物治疗有希望,但证据有限,特别是在年轻女性和非乳腺癌诊断方面. 阴道雌激素对生殖尿路症状是安全的, 但非激素的选择很少.

结论:

  • 在癌症后治疗更年期症状需要仔细考虑治疗的安全性和有效性.
  • 对于非激素治疗的证据存在重大差距,需要更多的研究.
  • 改善,集中和以患者为中心的护理模式对于解决经历更年期的癌症幸存者的未满足需求至关重要.