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通过重组细菌热转移试验和生化验证,探索与人类酸曼诺酶的联结体相互作用

Maria Monticelli1, Bruno Hay Mele2, Demi Marie Wright3

  • 1Institute of Biomolecular Chemistry ICB, CNR, Via Campi Flegrei 34, 80078, Pozzuoli, Italy; Department of Biology, University of Napoli "Federico II", Complesso Universitario Monte Sant'Angelo, Via Cinthia, 80126, Napoli, Italy.

Biochimie
|March 8, 2024
PubMed
概括

基化 (PMM2-CDG) 固有的基化障碍缺乏治愈方法. 研究人员证实,克洛德罗纳酸可选择性地与胺突变酶-1结合,这是PMM2-CDG的潜在治疗标.

关键词:
CeTSA CeTSA 是一个国家.在形码头对接.酸曼诺转基因-2 酶.蛋白质的稳定性 蛋白质的稳定性蛋白质 - 配方体结合在 ReBaTSA 中使用 ReBaTSA.

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Ligand Binding Sites02:40

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...