暴露于紫外线过器:发病率,影响,可能的分子作用机制和混合物内的相互作用
Alexandra Rafeletou1, Jenni Viivi Linnea Niemi1, Francisco Alejandro Lagunas-Rangel1
1Department of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden.
The Science of the total environment
|March 8, 2024
概括
紫外线过器,如氧松,通常与其他化学物质一起发生. 本综述详细介绍了20多个已确认的协同作用,突出显示了分子通路和参与它们相互作用的蛋白质.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
背景情况:
- 有机紫外线过器在个人护理产品中普遍存在,导致它们在人体样本和环境中广泛存在.
- 紫外线过器与其他化学物质 (如杀虫剂,双和) 的同时出现是常见的.
- 了解这些同时存在的物质的综合生物效应正引起越来越多的科学兴趣.
研究的目的:
- 审查和综合有关特定紫外线过器 (oxybenzone,ethylexyl-methoxycinnamate,4-methylbenzylidene camphor) 与其他化学品类同时发生的数据.
- 调查这些共同发生产生的潜在的协同作用,对抗作用或添加作用的生物效应.
- 阐明UV过器与其他化学物质相互作用的分子机制和关键生物途径.
主要方法:
- 文献审查侧重于报告特定紫外线过器与其他环境化学物质同时出现的研究.
- 分析已识别的相互作用,按作用分类 (协同作用,对抗作用,添加作用).
- 确定关键的分子通路和蛋白质,涉及到观察到的生物效应.
主要成果:
- 在11项涉及16种不同的化合物的研究中,确定了20多种已确认的协同作用.
- 突出显示的关键分子通路包括雌激素受体激活,雌激醇合成促进和甲状腺激素合成上调.
- 确定了重要的蛋白质标包括膜相关孕激素受体 (MAPR),细胞染色体P450和热冲击蛋白70 (Hsp70).
结论:
- 紫外线过器经常与一系列其他化学物质同时存在,具有复杂的生物相互作用潜力.
- 已识别的分子通路和蛋白质点为这些相互作用背后的机制提供了关键的见解.
- 需要进一步的研究,以充分了解这些联合暴露的毒理影响.
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