质子抑制剂,骨和的新陈代谢
Cécile Philippoteaux1, Julien Paccou2, Emmanuel Chazard3
1Rheumatology Department, Lille University Hospital, Lille, France; Public Health Department, University Lille, CHU de Lille, ULR 2694, CERIM, METRICS, Lille, France.
Joint bone spine
|March 8, 2024
概括
质子抑制剂 (PPI) 可能会增加骨折风险,并破坏和水平. 建议谨慎使用,特别是长期使用PPI的患者,因为可能存在骨健康问题.
科学领域:
- 胃肠病学 胃肠病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
背景情况:
- 质子抑制剂 (PPI) 是与酸有关的胃肠道问题的常见治疗方法.
- 人们对长期和不适当的PPI使用存在担忧.
- 新出现的证据将PPI与不良影响联系在一起,包括脏病,肺炎,痴呆症,心血管事件和骨健康问题.
研究的目的:
- 系统地审查PPI对骨健康的影响.
- 分析PPI对骨质疏松症,骨矿物密度 (BMD),骨折风险以及和代谢的影响.
主要方法:
- 对最近的研究进行了全面的文献分析.
- 检查关于PPI使用和骨健康结果的观察性研究和元分析.
- 专注于患有并发症的人群.
主要成果:
- 关于PPI和BMD的研究显示出混合的结果,需要进一步调查.
- 观察数据表明,在使用PPI时,骨折风险增加,特别是脊椎和部骨折,可能与剂量有关.
- PPI与和代谢的显著干扰有关,包括PPI诱导的低血症 (PPIH) 和二次低血症.
结论:
- 使用PPI与骨健康的潜在风险有关,包括骨折风险增加和代谢障碍.
- 虽然观察研究表明存在关联,但因果关系需要进一步研究.
- 谨慎的PPI处方实践至关重要,特别是在长期使用和类风湿病的情况下,以减轻潜在的危害.
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