健康新生儿人心中的心脏导电系统的3D模型
Brian Cottle1, Karl Schriewer1, Sarthak Tiwari1
1Department of Biomedical Engineering, University of Utah, 36 S. Wasatch Drive, MBB 3100, Salt Lake City, UT 84112, USA.
概括
高分辨率的3D模型揭示了儿科心脏心脏导电系统 (CCS) 的解剖变异. 这些模型突出了差异,比如女性和男性的深度,有助于外科精确度.
科学领域:
- 心血管解剖学的心血管解剖学
- 手术方面的创新.
- 儿科心脏病学 儿科心脏病学
背景情况:
- 心脏传导系统 (CCS) 的阳性损伤是先天性心脏手术中的重大风险.
- 目前的方法依赖于表面的解剖学标志,这可能无法解释解剖学变异性.
- 了解CCS变异性对于提高外科安全至关重要.
研究的目的:
- 在儿科心脏中创建心脏导电系统 (CCS) 的高分辨率3D模型.
- 为了评估鼻节 (SN) 和心房节 (AVN) 区域的解剖学变异性.
- 为外科医生提供关于CCS异质性的详细见解.
主要方法:
- 获得和处理儿科人类心脏 (平均捐赠者年龄为2.7天).
- 组织切割,染色和高分辨率成像管道的开发.
- 使用卷积神经网络精确的多类细分整个幻灯片图像,以生成3D模型.
- 创建10个AVN和8个SN结节组织区域模型,具有微米分辨率.
主要成果:
- 生成了AVN和SN组织区域的高分辨率3D模型,详细说明神经组织,血管和节点组件.
- 在节点区域内确定了新的解剖变异.
- 观察到His束深度的统计学上显著差异,女性儿科患者的平均深度比男性低304微米.
结论:
- 开发的3D模型提供了前所未有的细节,说明了儿科CCS的解剖异质性.
- 发现揭示了特定的变异,例如基于性别的差异,对于外科计划来说很重要.
- 这些模型增强了对CCS和周围结构之间的复杂关系的理解,有可能减少手术期间的阴性损伤.
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