调查益生菌对预防旅行者腹的影响:基于元分析的系统审查
Basmah F Alharbi1, Abeer A Alateek2
1Department of Basic Health Science, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia.
Travel medicine and infectious disease
|March 8, 2024
概括
特定的益生菌菌株可能有助于预防旅行者腹 (TD). 这次审查发现某些乳酸菌和Saccharomyces物种是有效的,强调需要对其他益生菌菌株进行进一步的研究,以预防TD.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 预防医学 预防医学
背景情况:
- 旅行者腹 (TD) 每年影响数百万人,抗生素和教育的成功有限.
- 以前的研究忽视了菌株特定的益生菌有效性和TD预防的益生菌.
- 本综述重点关注用于TD预防的益生菌,考虑剂量,持续时间和年龄.
研究的目的:
- 系统地审查益生菌在预防旅行者腹方面的有效性.
- 分析益生菌剂量,持续时间和年龄对TD预防的影响.
- 为了确定针对TD有效的特定益生菌菌株.
主要方法:
- 随机对照试验 (RCT) 的系统文献搜索,没有语言或出版年限.
- 纳入标准集中在人体RCT上,不包括动物和观察性研究.
- 该方法遵循了系统审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- 从166篇选论文中包括了10个RCT.
- 乳杆菌酸只在与其他菌株结合时才显示出有效性.
- 其他乳杆菌菌种提供高达39%的保护;Saccharomyces cerevisiae和Saccharomyces boulardii也是有效的.
结论:
- 对TD预防益生菌的研究有限;很少有菌株显示有效性.
- 特定的菌株,如Lactobacillus acidophilus,Lactobacillus rhamnosus,Lactobacillus fermentum,Saccharomyces cerevisiae和Saccharomyces boulardii,都显示出这种菌株的潜力.
- 对TD预防的额外益生菌菌株进行进一步的研究是有必要的.
相关概念视频
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
119
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
119
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
212
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
212
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
252
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
252
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Bacterial Flora of the Large Intestine
445
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
445
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
197
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
197


