肠道微生物群和口腔的遗传联系:孟德尔的随机化研究
Bilun Jin1, Pengfei Wang2, Peiqi Liu1
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
International dental journal
|March 8, 2024
概括
这项研究发现肠道细菌和口腔之间存在联系. 某些细菌可能会增加的风险,而其他细菌可能会提供保护,建议新的治疗途径.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 口服药是一种口服药.
背景情况:
- 肠道微生物群对整体健康起着至关重要的作用.
- 肠道细菌和口腔健康状况 (如口腔) 之间的关系尚不清楚.
研究的目的:
- 调查肠道微生物群组成和口腔的发生率之间的潜在因果关系.
- 为了确定与增加或减少患口腔的风险相关的特定肠道细菌种群.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 研究设计.
- 使用全基因组关联研究 (GWAS) 对肠道微生物群 (MiBioGen) 和口腔 (英国生物库) 的总结数据.
- 为了确保结果的有效性,进行了多种MR方法 (IVW,加权中位数,MR-Egger) 和灵敏度分析.
主要成果:
- 七种肠道细菌种群与口腔有显著的关联.
- 霍尔德曼尼亚菌,牛杆菌和鲁米诺可可菌 (UCG011) 植物与口腔有积极联系.
- 行为细菌,乳杆菌,奥斯基洛斯皮拉和Phascolarctobacterium与口腔有负面关联.
结论:
- 这项研究证实了肠道微生物质量与口腔之间的强烈关联.
- 鉴定到的肠道细菌可能是治疗和预防口腔的新治疗.
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